Sheikha Al Nafisi participated in the campaign for women to vote in Kuwait, up until 2005. She co-owned a contemporary art gallery in Kuwait from 2001 to 2005 and continues to be involved in the art scene in the Middle East. Al-Nafisi also has 7 years of restaurant consultancy experience and produced two T.V. cooking shows.

As a young ambassador for the “Hayatt Breast Cancer Foundation”, she has organized art events to raise funds and awareness. Al-Nafisi has been part of the “Peace One Day” organization team for 3 years in a row.